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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: FASEB J. 2020 May 4;34(6):8296–8309. doi: 10.1096/fj.202000214RR

FIGURE 5.

FIGURE 5

Deletion of UT decreased the CKD-induced increase in systolic blood pressure, suppressed cardiac fibrosis, and improved heart function. A, Systolic blood pressure (BP) were measured by tail-cuff method in WT and KO mice with or without Nx. B, Western blot analysis Tgf-β and α-SMA for lysates of mouse hearts. The right point graphs show the levels of each protein in the sham group compared with the level in the other three groups (designated as one-fold). Protein level normalized by total protein density of Ponceau S staining. Data: mean ± SEM (N = 4). *P < .05 by two-way ANOVA analysis. C, Echocardiography was performed on isoflurane anesthetized mice at 8 weeks after the surgery for mice. LVESD, left ventricular end-systolic dimension; LVESV, left ventricular end-systole volume