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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: FASEB J. 2020 May 4;34(6):8296–8309. doi: 10.1096/fj.202000214RR

FIGURE 6.

FIGURE 6

Inhibition of UT-A suppressed CKD-induced upregulation of renin and angiotensin-converting enzyme (ACE). Quantitative mRNA expression in mouse hearts performed by real-time PCR. All gene expressions were calculated by ΔΔcq and standardized by housekeeping gene 18s. A-C, mRNA from mice heart in sham/vehicle, sham/DMTU, 5/6Nx/vehicle, and 5/6Nx/DMTU mice. D-F, mRNA from mice heart in ET/sham, WT/CKD, KO/sham, and KO/CKD mice. A and D are Renin; B and E are ACE (angiotensin-converting enzyme); and C and F are Agtr1: angiotensin II receptor type 1. All data: mean ± SEM (N = 4-6). *P < .05, **P < .005 by one-way ANOVA analysis