TABLE 2.

Echocardiogram analysis of mice after 5/6 nephrectomy and DMTU treatment

	Sham + vehicle	Sham + DMTU	5/6Nx + vehicle	5/6Nx + DMTU
BW (g)	29.9 ± 0.4	25.8 ± 1.2	27.1 ± 0.8	25.8 ± 0.6
IVSs (mm)	1.05 ± 0.00	1.05 ± 0.00	1.17 ± 0.00*	1.08 ± 0.00†#
IVSd (mm)	0.47 ± 0.02	0.44 ± 0.00	0.51 ± 0.01*	0.49 ± 0.01
PWs (mm)	0.50 ± 0.02	0.52 ± 0.03	0.53 ± 0.01	0.52 ± 0.01
PWd (mm)	0.54 ± 0.02	0.53 ± 0.00	0.59 ± 0.01	0.55 ± 0.01
LVEDD (mm)	3.69 ± 0.12	3.80 ± 0.18	3.43 ± 0.18	3.43 ± 0.06
LVESD (mm)	2.37 ± 0.13	2.45 ± 0.14	3.34 ± 0.19*	2.77 ± 0.02†#
FS (%)	32 ± 1.5	33 ± 0.5	27 ± 0.5*	30 ± 0.5†
LVEDV (μL)	57.5 ± 1.0	57.3 ± 1.8	66.6 ± 0.6*	62.6 ± 0.3†#
LVESV (μL)	22.4 ± 1.4	21.8 ± 1.1	28.4 ± 0.4*	23.6 ± 0.3†#
LVM (mg)	89 ± 4	97 ± 7	113 ± 8*	89 ± 3†
LVMI (mg/g)	2.97 ± 0.09	3.73 ± 0.15	4.18 ± 0.27*	3.44 ± 0.13†#

Note: All data; mean ± SEM (N = 5-8).

Abbreviations: BW, body weight; FS, percentage of fractional shortening; calculated by 100*(LVEDD − LVESD)/LVEDD; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVEDD, left ventricular end-diastolic dimension; LVEDV, left ventricular end-diastolic volume; LVESV, left ventricular end-systolic volume; LVM, left ventricular mass; LVMI, left ventricular mass index (ratio of LVM to BW); PWd, posterior wall thickness at end-diastole; PWs, posterior wall thickness at end-systole.

^*P < .05 vs sham + vehicle;

^†P < .05 vs 5/6Nx + vehicle by one-way ANOVA with Bonferroni test;

^#P < .05 for interaction between 5/6Nx and DMTU (P < .0005 in IVSs, LVESD, LVEDV, and LVESV and P < .05 in LVMI for the factor of 5/6Nx; P < .05 in IVSs, LVESD, LVEDV, and LVESV and P = .95 in LVMI for the factor of DMTU) by two-way ANOVA.