TABLE 3.

Phenotypic characteristics of Wild-type and UT-KO mice

	WT		UT-KO
	WT/sham	WT/Nx	KO/sham	KO/Nx
BW (g)	29.2 ± 1.2	26.7 ± 0.3	30.5 ± 1.8	26.8 ± 0.6
BUN (mg/dL)	29.2 ± 1.8	52.3 ± 2.0*	26.3 ± 0.9	55.1 ± 1.7#
Urine urea (mmol/L)	1566 ± 114	1767 ± 216	304 ± 40	252 ± 60
24 hr urea (mmol/day)	4.767 ± 0.353	5.043 ± 0.311	3.824 ± 0.120	5.092 ± 0.529
24 hr intake volume/BW (mL/g)	0.213 ± 0.039	0.291 ± 0.021	0.621 ± 0.069	1.198 ± 0.185##
24 hr Urine volume/BW (mL/g)	0.110 ± 0.015	0.109 ± 0.011	0.436 ± 0.055	0.970 ± 0.183##
Volume in-out balance/BW (mL/g)	0.103 ± 0.025	0.181 ± 0.016**	0.184 ± 0.026	0.229 ± 0.019
24 hr Urine osmolality (mOsmol/kg H2O)	2289 ±140	2307 ± 288	636 ± 11	511 ± 52##
Plasma osmolality (mOsmol/kg H2O)	301 ± 2	309 ± 1**	306 ± 2	314 ± 3##

Note: 24 hr urea was calculated by Urine urea (mmol/L)*24 hr Urine volume (mL)/1000, Volume in-out balance/BW was calculated by {(24 hr intake volume) − (24 hr urine volume)} v/BW, All data; mean ± SEM (n = 5-6).

Abbreviations: BW, body weight; BUN, blood urea nitrogen.

^*P < .0001 vs WT-sham

^**P < .05 vs WT-sham

^#P < .0001 vs UT-A1/A3^−/−-sham

^##P < .05 vs UT-A1/A3^−/−-sham, by two-way ANOVA.