Table 3.

Mendelian randomization results for inflammatory biomarkers on probable lifetime major depression (moderate and severe)

Biomarker	Scale	OR (95% CI)	p-value
IL-1	Per 1 SD increase in IL-1Ra	1.06 (0.98–1.14)	0.17
IL-6	Per unit increase in log-transformed IL-6	1.35 (1.12–1.62)	0.0012
Fibrinogen	Per unit increase in log-transformed fibrinogen	0.96 (0.42–2.20)	0.92
TNF-alpha	Per TFN expression increasing allele	0.99 (0.96–1.02)	0.68
CRP	Per 1 unit increase in log-transformed CRP	1.18 (1.07–1.29)	0.0009
ICAM-1	Per 20 ng/dL increase in sICAM-1	1.01 (0.99–1.04)	0.22
P-selectin	Per P-selectin concentration increasing allele	0.97 (0.95–1.00)	0.16

Mendelian randomization estimates are odds ratios for depression (95% confidence intervals) either per unit increase in the risk factor or per allele as indicated