Table 4.
CogScreen results
| Subtest name | Domain | Measurement (including abbreviation) | ||||
|---|---|---|---|---|---|---|
| Accuracy | Speed | Throughput | Process | Feedback | ||
| Previous Number | Working memory | PNAACC | PNAItoC, PNAItoI | |||
| SAT Arrow Direction | Processing speed | SATADACC | SATADRTC | SATADPUT | ||
| SAT Arrow Color | Executive function | SATACACC | SATACRTC | SATACPUT | ||
| SAT Instruction | Working memory | SATINACC | SATINRTC | SATINPUT | SATIN_ItoI, SATIN_ItoC | |
| SATINRT_C, SATINRT_I | ||||||
| SAT Discovery | Executive function | SATDIACC | SATDIRTC | SATDIRUL | SATDI_ItoI, SATDI_ItoC | |
| SATDIFAI | SATDIRT_C, SATDIRRT_I | |||||
| SATDIPER | SATDIRTSD_C, SATDIRTSD_I | |||||
| Symbol Digit Coding | Processing speed | SDCACC | SDCSDRT | SDCCORR | ||
| Symbol Digit Coding Delayed Recall | Delayed memory | SDCDRACC | ||||
| Processing speed | Executive function | Working memory | Delayed memory | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SATADACC | SATADRTC | SATACACC | SATDIRTSD_I | SATIN_ItoI | SATINRT_I | SDCDRACC | ||||||||
| 40 mg | 80 mg | 40 mg | 80 mg | 40 mg | 80 mg | 40 mg | 80 mg | 40 mg | 80 mg | 40 mg | 80 mg | 40 mg | 80 mg | |
| Stage 1 | ||||||||||||||
| LS meana (95% CI) | −0.667 (−2.44, 1.10) | −0.463 (−2.20, 1.27) | 0.076 (0.02, 0.13) | 0.022 (−0.03, 0.08) | −1.248 (−4.98, 2.49) | 0.097 (−3.58, 3.77) | 42 (−45, 130) | 156 (70, 242) | −0.005 (−0.46, 0.45) | 0.129 (−0.32, 0.58) | 93 (−255, 443) | 314 (−2, 631) | −2.387 (−11.35, 6.58) | −4.345 (−13.20, 4.51) |
| p value | 0.458 | 0.599 | 0.009 | 0.443 | 0.511 | 0.958 | 0.341 | <0.001 | 0.982 | 0.571 | 0.594 | 0.052 | 0.600 | 0.334 |
| Cohen’s d | −0.14 | −0.10 | 0.50 | 0.14 | −0.124 | 0.010 | 0.18 | 0.67 | −0.004 | 0.106 | 0.16 | 0.53 | −0.099 | −0.181 |
| Stage 2 | ||||||||||||||
| LS meana (95% CI) | −2.016 (−6.03, 2.00) | −3.611 (−7.41, 0.19) | 0.036 (−0.05, 0.13) | 0.023 (−0.06, 0.11) | −5.055 (−10.21, 0.10) | −4.552 (−9.50, 0.40) | 45 (−123, 213) | −71 (−235, 91) | 0.687 (0.11, 1.26) | 0.430 (−0.12, 0.98) | 539 (−70, 1148) | 384 (−251, 1020) | −24.658 (−39.52, −9.80) | −15.323 (−29.58, −1.06) |
| p value | 0.318 | 0.062 | 0.418 | 0.599 | 0.054 | 0.071 | 0.593 | 0.383 | 0.020 | 0.125 | 0.080 | 0.224 | 0.002 | 0.036 |
| Cohen’s d | −0.35 | −0.63 | 0.27 | 0.17 | −0.66 | −0.59 | 0.18 | −0.29 | 0.81 | 0.51 | 0.82 | 0.59 | −1.12 | −0.69 |
| Combined | ||||||||||||||
| ANCOVA p | 0.221 | 0.051 | 0.034 | 0.387 | 0.048 | 0.150 | 0.356 | 0.363 | 0.064 | 0.118 | 0.065 | 0.044 | 0.002 | 0.019 |
SATADACC SAT-Arrow Direction Accuracy (% accurate response, 100% = perfect), SATADRTC SAT-Arrow Direction Speed (s), SATACACC SAT-Arrow Color Accuracy (% accurate response, 100% = perfect), SATDIRTSD_I SAT-Discovery Reaction Time Variability Following Incorrect Response (ms), SATIN_ItoI SAT-Instruction Number Incorrect Following Incorrect Response (count), SATINRT_I SAT-Instruction Reaction Time Following Incorrect Response (ms), SDCDRACC SDC-Delayed Recall Accuracy (% accurate response, 100% = perfect), LS mean least-squares mean, ANCOVA analysis of covariance
*t Tests with p ≤ 0.05
a LS means are from the ANCOVA model for differences between active and placebo groups
Bold font indicates p values < 0.05