Table 6.
Exposure-related organ weight changes
| Type | Parameter | Sex | Exposed | Recovery | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PG/VG + Nic | PG/VG + F-Med | PG/VG + Nic + F-Low | PG/VG + Nic + F-Med | PG/VG + Nic + F-High | PG/VG + Nic | PG/VG + Nic + F-High | ||||
| Absolute weight after exsanguination | Adrenal gland weight (g) | M | ↥** | ↥ | ↥** | ↥* | ↥ | ↧*** | ↧** | |
| F | ↥*** | ↥ | ↥*** | ↥** | ↥*** | ↧*** | ↧*** | |||
| Brain weight (g) | M | ↧ | ↧ | ↧ | ↧* | ↧ | ↥ | ↥** | ||
| F | ↧ | ↧ | ↧ | ↧ | ↥ | ↥ | ↧ | |||
| Epididymis weight (g) | M | ↥ | ↥ | ↥* | ↥ | ↥ | ↥* | ↥*** | ||
| Heart weight (g) | M | ↥ | ↧ | ↧ | ↧ | ↧ | ↥* | ↥*** | ||
| F | ↥* | ↥ | ↥* | ↥** | ↥** | ↥ | ↧ | |||
| Kidney weight (g) | M | ↧ | ↥ | ↥ | ↥ | ↧ | ↥** | ↥** | ||
| F | ↥ | ↥ | ↥** | ↥** | ↥** | ↥ | ↧ | |||
| Liver weight (g) | M | ↧ | ↧ | ↥ | ↧ | ↧ | ↥** | ↥* | ||
| F | ↥** | ↧ | ↥** | ↥** | ↥*** | ↧* | ↧* | |||
| Lung, larynx, and trachea weight (g) | M | ↧ | ↧ | ↧ | ↥ | ↧ | ↥* | ↥* | ||
| F | ↥ | ↥ | ↥* | ↥* | ↥* | ↥ | ↥ | |||
| Ovary weight (g) | F | ↥** | ↥ | ↥** | ↥ | ↥** | ↧ | ↧ | ||
| Spleen weight (g) | M | ↧* | ↥ | ↧* | ↧** | ↧** | ↥*** | ↥*** | ||
| F | ↥ | ↥ | ↥ | ↥ | ↥ | ↥* | ↥* | |||
| Testes weight (g) | M | ↥ | ↥ | ↥ | ↥ | ↥ | ↥* | ↥* | ||
| Thymus weight (g) | M | ↧* | ↥ | ↧* | ↧** | ↧* | ↥** | ↥* | ||
| F | ↧ | ↥ | ↧ | ↧ | ↧ | ↥** | ↥* | |||
| Thyroid and parathyroid weight (g) | M | ↥ | ↧ | ↧ | ↧ | ↥ | ↧ | ↥ | ||
| F | ↥* | ↥ | ↥ | ↥* | ↥* | ↧ | ↥ | |||
| Uterus and cervix weight (g) | F | ↥ | ↥* | ↧ | ↧* | ↥ | ↥ | ↥* | ||
| Weight relative to body weight | Adrenal gland weight | M | ↥*** | ↥ | ↥*** | ↥** | ↥** | ↧*** | ↧*** | |
| F | ↥** | ↥ | ↥** | ↥ | ↥* | ↧*** | ↧*** | |||
| Brain weight | M | ↥* | ↥ | ↥ | ↥ | ↥ | ↧*** | ↧*** | ||
| F | ↧* | ↧ | ↧*** | ↧*** | ↧** | ↧ | ↧* | |||
| Epididymis weight | M | ↥* | ↥ | ↥* | ↥* | ↥* | ↧ | ↥ | ||
| Heart weight | M | ↥* | ↥ | ↥ | ↥ | ↥ | ↧ | ↧ | ||
| F | ↥ | ↥ | ↥ | ↧ | ↧ | ↧ | ↧* | |||
| Kidney weight | M | ↥ | ↥ | ↥* | ↥* | ↥ | ↧ | ↧ | ||
| F | ↧ | ↧ | ↥ | ↧ | ↥ | ↧ | ↧*** | |||
| Liver weight | M | ↥ | ↥ | ↥* | ↥* | ↥ | ↥ | ↧ | ||
| F | ↥ | ↧* | ↥** | ↥ | ↥ | ↧*** | ↧*** | |||
| Lung, larynx, and trachea weight | M | ↥** | ↥ | ↥* | ↥*** | ↥** | ↧ | ↧*** | ||
| F | ↧ | ↥ | ↧ | ↧ | ↧ | ↧ | ↧ | |||
| Ovary weight | F | ↥ | ↥ | ↥** | ↥ | ↥* | ↧* | ↧ | ||
| Spleen weight | M | ↧ | ↥ | ↧ | ↧ | ↧ | ↥ | ↥** | ||
| F | ↧ | ↥ | ↧ | ↧ | ↧ | ↥ | ↥ | |||
| Testes weight | M | ↥ | ↥ | ↥ | ↥ | ↥* | ↧* | ↧** | ||
| Thymus weight | M | ↧ | ↥ | ↧ | ↧* | ↧ | ↥ | ↥ | ||
| F | ↧* | ↥ | ↧* | ↧* | ↧* | ↥** | ↥* | |||
| Thyroid and parathyroid weight | M | ↥ | ↧ | ↥ | ↧ | ↥ | ↧ | ↧ | ||
| F | ↥ | ↥* | ↥ | ↥ | ↥ | ↧ | ↧ | |||
| Uterus and cervix weight | F | ↥ | ↥* | ↧* | ↧** | ↧ | ↥ | ↥ | ||
| Weight relative to brain weight | Adrenal gland weight | M | ↥** | ↥ | ↥** | ↥* | ↥* | ↧*** | ↧** | |
| F | ↥*** | ↥ | ↥*** | ↥** | ↥*** | ↧*** | ↧*** | |||
| Epididymis weight | M | ↥ | ↥ | ↥* | ↥ | ↥ | ↥* | ↥*** | ||
| Heart weight | M | ↥ | ↥ | ↧ | ↧ | ↧ | ↥* | ↥** | ||
| F | ↥* | ↥ | ↥** | ↥** | ↥* | ↥ | ↧ | |||
| Kidney weight | M | ↧ | ↥ | ↥ | ↥ | ↧ | ↥** | ↥* | ||
| F | ↥ | ↥ | ↥** | ↥** | ↥* | ↥ | ↧ | |||
| Liver weight | M | ↧ | ↧ | ↥ | ↥ | ↧ | ↥** | ↥ | ||
| F | ↥** | ↧ | ↥*** | ↥** | ↥** | ↧ | ↧ | |||
| Lung, larynx, and trachea weight | M | ↥ | ↧ | ↥ | ↥ | ↥ | ↥* | ↥ | ||
| F | ↥* | ↥ | ↥* | ↥ | ↥ | ↥ | ↥ | |||
| Ovary weight | F | ↥** | ↥ | ↥*** | ↥* | ↥** | ↧ | ↧ | ||
| Spleen weight | M | ↧ | ↥ | ↧ | ↧* | ↧* | ↥*** | ↥*** | ||
| F | ↥ | ↥* | ↥ | ↥ | ↥ | ↥* | ↥** | |||
| Testes weight | M | ↥ | ↥ | ↥ | ↥ | ↥ | ↥ | ↥ | ||
| Thymus weight | M | ↧* | ↥ | ↧* | ↧* | ↧* | ↥** | ↥* | ||
| F | ↧ | ↥ | ↧ | ↧ | ↧ | ↥** | ↥* | |||
| Thyroid and parathyroid weight | M | ↥ | ↧ | ↧ | ↧ | ↥ | ↧ | ↥ | ||
| F | ↥* | ↥* | ↥ | ↥* | ↥* | ↧ | ↥ | |||
| Uterus and cervix weight | F | ↥ | ↥* | ↧ | ↧* | ↥ | ↥* | ↥* | ||
Symbols, ↓ indicates response lower in Exposed relative to PBS (measured at identical time point); = indicates no difference; ↑ indicates response higher in Exposed relative to PBS (measured at identical time point); while the Recovery groups are compared against the same treatment group from Exposed
Significance: *p < 0.05; **p < 0.01; ***p < 0.001
M male, F female
For detailed data, see Supplemental Table 13