Table 4.
Relationships between serum iron, ferritin, and hepcidin levels and osteoporosis-related factors analyzed by multiple regression.
| Fe | Ferritin | Log (hep + 1) | ||||
|---|---|---|---|---|---|---|
| β | p | β | p | β | p | |
| Femoral T score | 0.121 | 0.039 | 0.028 | 0.631 | 0.012 | 0.840 |
| Femoral Z score | 0.123 | 0.046 | 0.048 | 0.449 | 0.059 | 0.362 |
| Bone alkaline phosphatase | 0.101 | 0.118 | −0.027 | 0.677 | −0.040 | 0.543 |
| TRACP-5b | −0.067 | 0.294 | −0.079 | 0.222 | −0.058 | 0.383 |
| 25(OH)D | 0.044 | 0.493 | 0.200 | 0.002 | 0.207 | 0.002 |
| FGF-23 | 0.090 | 0.146 | 0.103 | 0.096 | 0.029 | 0.653 |
| MMP-3 | −0.046 | 0.402 | 0.160 | 0.004 | −0.015 | 0.790 |
| Annual change of femoral T score* | 0.000 | 0.996 | −0.132 | 0.056 | −0.031 | 0.659 |
| Annual change of lumbar T score* | 0.013 | 0.851 | 0.085 | 0.225 | 0.159 | 0.025 |
Multiple regression models were adjusted for age, sex, BMI, eGFR, CRP, PSL use, bDMARD use, anti-resorption drug use, teriparatide use, and iron agent use.
TRACP-5b, tartrate-resistant acid phosphatase-5b; 25(OH)D, 25-hydroxy vitamin D; FGF23, fibroblast growth factor 23; MMP-3, matrix metalloprotease 3.
*Annual change of T score was evaluated in 231 patients and the mean observational period was 2.0 ± 0.33 years (0.63–3.25).