Table 2.

Comparison of canonical pathway analysis for the group comparisons “In vivo’’ and “Matured’’ based on log2 fold change (used cut offs: FC > 2; p < 0.05) using ingenuity pathway analysis (IPA).

Canonical Pathway	“In vivo” (Matured VS Failed to mature)	“Matured” (In vivo VS In vitro)
LXR/RXR Activation	4.26	4.38
Intrinsic Prothrombin Activation Pathway	1.89	1.41
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages	0.82	2.33
Acute Phase Response Signaling	1.79	1.34
IL-8 Signaling	−2.12	−0.45
Nitric Oxide Signaling in the Cardiovascular System	−1.41	−1.13
Neuregulin Signaling	−1.34	−1.00
PDGF Signaling	−1.34	−1.00
PAK Signaling	−1.34	−1.00
Calcium-induced T Lymphocyte Apoptosis	2.24	N/A
Non-Small Cell Lung Cancer Signaling	−1.00	−1.00
STAT3 Pathway	−2.00	N/A
Integrin Signaling	−0.58	1.41
NRF2-mediated Oxidative Stress Response	0.00	−1.89
PPARÎ ± /RXRÎ ± Activation	0.71	1.13
ILK Signaling	0.71	1.13
GNRH Signaling	−0.82	−0.45
Glioma Invasiveness Signaling	0.82	0.45
p70S6K Signaling	−0.82	−0.45
PTEN Signaling	0.82	0.45
Cholecystokinin/Gastrin-mediated Signaling	−1.13	0.00
Thrombin Signaling	−0.71	0.38
Agrin Interactions at Neuromuscular Junction	−1.00	N/A
EGF Signaling	−1.00	N/A
Coagulation System	0.53	−0.28
Ephrin Receptor Signaling	−0.33	0.45
IL-6 Signaling	0.45	0.00
Huntington’s Disease Signaling	0.45	0.00
G Beta Gamma Signaling	−0.45	0.00
Regulation of Cellular Mechanics by Calpain Protease	−0.38	0.00
Osteoarthritis Pathway	0.00	0.38