Fig. 7. DLEU2 increases PIK3CD expression to promote LSCC cell proliferation and metastasis in vivo.

a Tumor size was measured when the animal was sacrificed. b, c The growth curve (b) and tumor weights (c). d Proliferative ability was evaluated by immunohistochemistry of Ki-67 (original magnification: ×200; scale bar = 25 µm). e Left: representative bioluminescent images obtained at 4 weeks after tail vein injection of Hep2 cells. Right: quantification of bioluminescent imaging signal intensity, as detected using a noninvasive in vivo imaging system. *P < 0.05, **P < 0.01, ***P < 0.001.