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. 2020 Jun 18;10:9884. doi: 10.1038/s41598-020-65908-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Behavioral assays for social interaction and novelty in APP/PS1 and WT mice on a Hfd or normal chow at 10 and 19 months of age. Groupwise averages for the 3-chamber sociability score, measured as direct interaction time with the stranger vs. an empty chamber (A) and time spent in chamber with the stranger vs. the empty chamber (B), at 10 and 19 months of age. Groupwise averages for the 3-chamber social novelty score, measured as direct interaction time with the novel stranger vs. the old stranger (C) and time spent in chamber with the novel stranger vs. the chamber with the old stranger (D), at 10 and 19 months of age. Animal numbers for all measurements — 10 months: APP/PS1-NC: n = 9; WT-NC: n = 11; APP/PS1-Hfd: n = 13; WT-Hfd: n = 13; 19 months: APP/PS1-NC: n = 5; WT-NC: n = 8; APP/PS1-Hfd: n = 10; WT-Hfd: n = 11; *p < 0.05 between genotypes (APP/PS1 vs. WT); one-way ANOVA with Holm-Šídák multiple comparisons correction.