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. 2020 Jun 18;10:9898. doi: 10.1038/s41598-020-66728-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Different cell populations show expression of specific markers. (a) Gene expression of markers specific to inflammatory Ly6C^high (Cx3cr1^mid Ccr2⁺ Cd62l⁺ Cd43^low Treml4⁺) and patrolling Ly6c^low (Cx3cr1^high Ccr2^- Cd62l^- Cd43^high Treml4^-) monocytes (b) Normalized read counts of cell markers used to identify and differentiate monocytes from macrophages (CCR2^high and CCR2^low), including Ly6C, Ccr2, Cx3cr1, Fcgr1, Mertk, Itgax, Ptprc, Adgre1, Mrc1, Ccr7 and Nr4a1. (c) Expression of activation markers Cd74, H2-Aa, H2-Eb1, IL1b (d) Arg1, H2-DMb1, Il4ra, Tnf (E) Mrc1, Cd80, Cd86 and Nos2 shows that after infiltration into the glioma monocytes and macrophages are in an activated state. Data represents 3 independent experiments and are presented as the mean with SEM (error bars). Differential expression analysis with fold₂change, SEM and adjusted p-values are listed in Supplementary Table S1.