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. 2020 Jun 19;10:198. doi: 10.1038/s41398-020-00888-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Circular Manhattan plots for (A) clozapine serum concentration, (B) N-desmethylclozapine serum concentration, and (C) Clozapine-N-desmethylclozapine metabolic ratio. The inner plot shows the results from the initial GWAS without controlling for smoking habits. The outer plot shows the results of the GWAS after controlling for smoking habits. The −log10 transformed p-values for each SNP are indicated on the y-axes and chromosomal positions along the exterior of the plot. The dashed red line represents the threshold for significant associations (p<5×10⁻⁸). SNPs surpassing this threshold are indicated in red.