Table 2.

Association statistics and effect sizes of the lead SNPs for each phenotype and genomic locus from the GWASs, without or with controlling for smoking habits.

Phenotype and locus	Lead SNP	Position: alleles	Effect allele	GWAS p	Beta	SE	Annotation	Nearest gene	Distance to gene	CADD	RDB	Min Chr state	Common Chr state
Statistics without controlling for smoking habits:
N-desmethylclozapine:
4:69601886–70138176	rs1670747	69610466: G/A	A	1.616 × 10−8	−0.183	0.032	Intergenic	RP11-1267H10.4	32249	2.713	NA	2	15
Metabolic Ratio:
4:69535335–70387482	rs1513559	69655555: A/G	G	4.819 × 10−27	0.246	0.021	Intergenic	CTD-2005D20.1	2362	0.004	5	9	15
Statistics controlling for smoking habits:
Clozapine:
9:14163907–14163907	rs28379954	14163907: T/C	C	1.677 × 10−8	−0.376	0.065	Intronic	NFIB	0	8.433	7	5	15
N-desmethylclozapine:
4:69601886–70138176	rs1670747	69626729: G/A	A	5.805 × 10−10	−0.215	0.034	Intergenic	RP11-1267H10.4	32249	2.713	NA	2	15
Metabolic ratio:
4:69544277–70340670	rs292638	69662832: C/G	G	2.067 × 10−23	0.247	0.023	Intergenic	CTD-2005D20.1	9639	2.223	5	5	15

CADD = Combined Annotation-Dependent depletion score, which predict how deleterious the SNP effect is on protein structure/function (higher scores indicate more deleterious); RegulomeDB (RDB) scores predict likelihood of regulatory functionality (lower scores indicate higher likelihood); min Chr State = minimum chromatin state across 127 tissue types (lower scores indicate more open chromatin); common Chr State = most common chromatin state in 127 tissue types.