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. 2020 Jun 18;10:9907. doi: 10.1038/s41598-020-66735-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Principal component analysis (PCA) of patient and donor samples. PCA was performed on 19 Keratoconus (7 KC and 12 KJ) and 10 control (7 DN and 3 LE) corneas using 10,652 genes with FPKM value ≥ 5 in at least one sample. Technical duplicates of 7 KC and 1 DN samples (KC*_2 and DN401_2) appear close together. The major separation along PC1 was between KCN and controls. KC and KJ samples cluster together along PC1. African American donor (DN) and KC patient samples are labeled purple and red, respectively; Caucasian donors (LE) are in blue and Middle Eastern patients (KJ) in green. Euclidean distance between samples in a pairwise comparison of samples in PC1 and PC2 is shown in Supplemental Table S3.