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. 2020 Jun 18;10:9906. doi: 10.1038/s41598-020-66899-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Matlab elaboration of the FE results for patient C-8, highlighting the presence of PVL in the non-coronary cusps (NCC) of the valve (red asterisks). (b) Transthoracic echocardiographic 5 chamber view for the same patient: one jet of paravalvular regurgitation (PVL) is showed by the green arrow in the non-coronary cusp. The ECG shows that the image was taken during diastole, i.e during the bioprosthetic valve closure. RV = right ventricle, RA = right atrium; LA = left atrium; LV = left ventricle; R = right coronary cusp; L = left coronary cusp; N = non-coronary cusp.