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. 2020 Jun 18;10:9921. doi: 10.1038/s41598-020-64257-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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gcCbfb;Runx2KO mice failed to ovulate. (A & B) Immature wild-type and gcCbfb;Runx2KO mice primed with PMSG/hCG were killed between 16–24 h after hCG administration and cumulus oocyte complexes (COCs) were collected from oviducts and counted (A), and their ovarian morphology was examined (B) (n = 13 and 8 for control and mutant mice, respectively). *p < 0.001. (C & D) Adult mice were euthanized in the morning of estrus (marked as E* in Fig. 1F). COCs were collected from oviducts and counted (C), and their ovarian morphology was examined (D) (n = 5 and 9 for control and mutant mice, respectively). *p < 0.001. Arrows and arrowheads point to large antral follicles with expanded cumulus cells and newly forming CL, respectively. pCL; CL generated from previous cycles. F; follicle. Scale bars, 500 μm for all images.