Table 2.
A list of selected up-regulated genes in gcRunx2;CbfbKO mice.
| Official Gene Name | Fold change |
|---|---|
| Hsd17b1 (hydroxysteroid (17-beta) dehydrogenase 1)* | 2.72 |
| Vcam1 (vascular cell adhesion molecule 1) | 2.91 |
| Inhbb (inhibin beta-B)* | 4.30 |
| Grem1 (gremlin 1, DAN family BMP antagonist)* | 4.46 |
| Cyp17a1 (cytochrome P450, family 17, subfamily a, polypeptide 1) | 6.16 |
| Gpr83 (G protein-coupled receptor 83) | 9.71 |
*, genes which were previously identified to be differentially regulated in cultured granulosa cells isolated from Cbfbflox/flox;Cyp19cre mice compared to those from wild-type mice9.
Fold changes were calculated by comparing the average values for mutant mouse samples vs. littermate control mouse samples (gcRunx2;CbfbKO/Wild-type). Lower expression in mutant mouse samples is given as −2 rather than 0.5. The genes verified by qPCR were highlighted in green and red in Table 1 and Table 2, respectively.