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. 2020 Jun 18;11:3102. doi: 10.1038/s41467-020-16924-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic illustration of the NIR-II imaging setup to monitor the opening and recovery of the BBB. b The NIR-II images of the mice brain before and after treated with focused ultrasound (FUS) and microbubbles at different time points (n = 3 mice). The green and violet circles and arrows indicate the opening and recovering points of cerebral vessels. Corresponding normalized mean signal intensity of green (c) and violet a (d) circles as a function of time. The fluorescence intensity region (noted as the yellow circle) of each images was normalized to measure the signal intensity decreasing process of the leakage on the brain vessels. Data point with its error bar stands for mean ± s.d. derived from n = 3 replicated measurements. Scale bar represents 4 mm. Source data underlying c and d are provided as a Source Data file.