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. 2020 Jun 12;10:819. doi: 10.3389/fonc.2020.00819

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Copyright © 2020 Datta, Kok, Crezee, Gaipl and Bodis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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An illustrative example of a patient with locally advanced pancreatic cancer being treated with hyperthermia and radiotherapy as per the HEATPAC protocol (264). Multisensor thermometry probes are guided through the endoscope and placed in the duodenum. Hyperthermia treatment plan is obtained using HYPERPLAN, and the online temperature monitoring is carried out during the hyperthermia. The tumor shows metabolic complete remission on PET obtained at 6 months following the treatment with hyperthermia, radiotherapy, and chemotherapy (HTCTRT).