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. 2020 Jun 12;10:819. doi: 10.3389/fonc.2020.00819

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Copyright © 2020 Datta, Kok, Crezee, Gaipl and Bodis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Integration of hyperthermia in clinical practice along with other treatment modalities is supported by its thermobiological rationale and clinical evidences reported from various phase III randomized trials and meta-analysis of various tumors sites. ReRT, reirradiation; HT, hyperthermia; RT, radiotherapy; HTRT, thermoradiotherapy; CTRT, chemoradiotherapy; NACT, neoadjuvant chemotherapy; PRFS, proton resonance frequency shift. The images of RT, HT, and HTRT plans have been modified and reproduced with permission from van Leeuwen et al. (262).