TABLE 2.

Effects of pathogenic mutants.

					PFF treatment of neuron			PFF treatment of microglia			Microinjection in SNpc
Mutation	Onset age	Secretion	mRNA	Aggregation	Intracellular α -syn	Toxicity	Oxidative stress	Intracellular α -syn	Toxicity	Oxidative stress	P-alpha-synuclein	Neuro-inflammation
A18T	Late			+							NA	NA
A29S	Late			+							NA	NA
A30P	Late			+ /−			+				NA	NA
E46K	Early		+ +	+ +	+ + +		+	+ + +
H50Q	Early	+ + +		+ + +	+ + +		+ +	+ + +			+ + +	+ + +
G51D	Early			−−−			+	+ + +			+ + +	+ + +
A53E	Early		−−	−			+ +				NA	NA
A53T	Early	+ + +	+ +	+ +		+	+				+ + +	+ + +

Compared to WT: “+” <20% increase; “+ +” 20–50% increase; “+ + +” >50% increase. “−“<20% decrease; “−−” 20–50% decrease; “−−−“>50% decrease.