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. 2020 Jun 12;11:1186. doi: 10.3389/fimmu.2020.01186

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Copyright © 2020 Lim, Porter, Orandle, Green, Barnes, Croston, Wolfarth, Battelli, Andrew, Beezhold, Siegel and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantitative measurement of pro-inflammatory LMs and SPMs in mouse WLL fluids. Mice were treated as described in Figure 2 legend and were examined for the levels of specialized LMs in the WLL fluid. Proinflammatory LMs LTB4 (A) and PGE2 (B), or SPMs RvD1 (C), LXA4 (D), and RvE1 (E) were quantitatively measured using ELISA (n = 6). The ratio of fold change for RvD1/LTB4 (F) or RvD1/PGE2 (G) was further calculated for MWCNT- or C60F-treated samples at day 1 and day 7. *p < 0.05; **p < 0.01; ***p < 0.001.