Table 2.
Statistical analysis for gender-related issues.
| Male = 35 (57.38%) | Female = 26 (42.62%) | FET | MWUT | |||||
|---|---|---|---|---|---|---|---|---|
| Count (%) | Mean (SD) | n | Count (%) | Mean (SD) | n | |||
| Age at disease onset | 30.54 (13.92) | 35 | 34.77 (16.91) | 26 | NS | |||
| Age at examination | 47.03 (11.50) | 35 | 47.42 (16.74) | 26 | NS | |||
| Disease duration | 16.49 (9.22) | 35 | 12.65 (9.29) | 26 | NS | |||
| BMI | 24.94 (5.01) | 35 | 23.23 (4.35) | 26 | NS | |||
| BMI≥30 | 6 (17.1%) | 35 | 2 (7.7%) | 26 | NS | |||
| (CTG)n | 427.87 (260.17) | 31 | 506.05 (282.94) | 22 | NS | |||
| MIRS score | 2.94 (0.80) | 35 | 2.81 (0.90) | 26 | NS | |||
| Comorbidities | ||||||||
| Hypertension | 6 (17.1%) | 5 (19.2%) | NS | |||||
| Steatosis | 14 (40.0%) | 35 | 7 (26.9%) | 26 | NS | |||
| Diabetes type II | 5 (14.3%) | 35 | 1 (3.8%) | 26 | NS | |||
| Cholelithiasis | 9 (25.7%) | 35 | 10 (38.5%) | 26 | NS | |||
| Cholecistectomy | 7 (20.0%) | 35 | 5 (19.2%) | 26 | NS | |||
| Hepatitis C | 0 (0%) | 35 | 1 (3.8%) | 26 | NS | |||
| ≥1 GI symptoms | 21 (60.0%) | 35 | 23 (88.5%) | 26 | 0.020 | |||
| GERD | 14 (40%) | 35 | 10 (38.5%) | 26 | NS | |||
| GERD (GSRS score) | 2.20 (1.71) | 2.12 (1.70) | NS | |||||
| Abdominal discomfort | 11 (31.4%) | 35 | 16 (61.5%) | 26 | 0.036 | |||
| Abdominal discomfort (GSRS score) | 1.91 (1.72) | 2.85 (1.80) | 0.017 | |||||
| Abdominal pain | 8 (22.9%) | 35 | 12 (46.2%) | 26 | NS | |||
| Abdominal pain (GSRS score) | 1.51 (1.22) | 2.53 (1.90) | 0.021 | |||||
| Constipation | 11 (31.4%) | 35 | 17 (65.4%) | 26 | 0.011 | |||
| Constipation (GSRS score) | 2.06 (1.75) | 3.04 (1.82) | 0.020 | |||||
| Diarrhea | 11 (31.4%) | 35 | 13 (50%) | 26 | NS | |||
| Diarrhea (GSRS score) | 1.69 (1.16) | 2.15 (1.62) | NS | |||||
| Alternating constipation/diarrhea | 5 (14.3%) | 1.69 (1.16) | 35 | 10 (38.5%) | 26 | 0.039 | ||
| Medications | ||||||||
| Mexiletine | 9 (25.7%) | 35 | 5 (19.2%) | 26 | NS | |||
| Anti-hypertensives | 6 (17.1%) | 35 | 5 (19.2%) | 26 | NS | |||
| Aspirin | 6 (17.1%) | 35 | 5 (19.2%) | 26 | NS | |||
| Insulin | 2 (5.7%) | 35 | 1 (3.8%) | 26 | NS | |||
| Metformin | 2 (5.7%) | 35 | 3 (11.5%) | 26 | NS | |||
| Ursodeoxycholic acid | 5 (14.3%) | 35 | 0 (0%) | 26 | NS | |||
| Hypolipidemic drugs | 9 (25.7%) | 35 | 5 (19.2%) | 26 | NS | |||
| Anti-constipation medicines | 4 (11.4%) | 35 | 3 (11.5 %) | 26 | NS | |||
| PPIs | 13 (37.1%) | 35 | 8 (30.8%) | 26 | NS | |||
| Probiotics | 3 (8.6%) | 35 | 1 (3.8%) | 26 | NS | |||
| Vitamine D supplements | 19 (54.3%) | 35 | 11 (42.3%) | 26 | NS | |||
| Blood tests | ||||||||
| Glucose | 92.57 (29.82) | 35 | 90.77 (22.34) | 26 | NS | |||
| Glucose out of range (>110 UI/l) | ||||||||
| GPT | 43.94 (26.45) | 33 | 30.92 (20.46) | 24 | 0.006 | |||
| GPT out of range (>45 UI/l) | 13 (60.6%) | 33 | 4 (16.7%) | 24 | NS | |||
| GGT | 103.23 (89.71) | 35 | 67.20 (115.08) | 25 | 0.002 | |||
| GGT out of range (>36 UI/l) | 28 (80%) | 35 | 11 (44%) | 25 | 0.006 | |||
| Alkaline phosphatase | 76.70 (26.60) | 33 | 87.29 (38.11) | 21 | NS | |||
| Amylase | 60.71 (34.41) | 28 | 54.94 (21.22) | 17 | NS | |||
| Total cholesterol | 186.20 (43.23) | 35 | 191.17 (37.19) | 24 | NS | |||
| Triglycerides | 161.31 (76.66) | 35 | 139.42 (61.48) | 24 | NS | |||
| Vitamine D | 24.65 (12.28) | 28 | 24.89 (14.39) | 20 | NS | |||
| Vitamine D below the normal range (<30 UI/l) | 19 (67.9%) | 28 | 13 (65.0%) | 20 | NS | |||
| Creatinine | 0.84 (0.25) | 34 | 0.63 (0.19) | 25 | 0.001 | |||
| Erythrocyte Sedimentation Rate | 10.62 (10.77) | 26 | 19.30 (22.67) | 20 | NS | |||
| Intestinal permeability (IP) | ||||||||
| Total IP | 6.94 (5.02) | 33 | 6.40 (3.97) | 24 | NS | |||
| Altered | 31 (93.9%) | 33 | 21 (87.5%) | 24 | NS | |||
SD, standard deviation; BMI, Body Mass Index; MIRS, muscular impairment rating scale; GI, gastrointestinal; GERD, gastroesophageal reflux disease; GSRS, Gastrointestinal Symptom Rating Scale; NAFLD, non-alcoholic fatty liver disease; PPI, proton pump inhibitor; IP, intestinal permeability; FET, Fishers' exact test; MWUT, Mann-Whitney U Test. Bold indicates statistical significance of values.