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. 2020 Jun 12;11:812. doi: 10.3389/fphar.2020.00812

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Copyright © 2020 Liu, Zhu, Guo, Lin, Wang, Gu, Dong, Zhou, Wang and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SB216763 and Nec-1 reduces the fluorescence intensity of glial fibrillary acidic protein (GFAP) and neurocan in astrocytes after ischemia/reperfusion (I/R) in rats. SB216763 (400 pmol) or Nec1 (48 nmol) was intracerebroventricularly administered before ischemia. (A) Representative images of GFAP, neurocan, and Hoechst staining in the peri-infarct zones of the sham or cerebral ischemic cortex at 7 d after reperfusion following tMCAO for 90 min (GFAP: red; neurocan: green; Hoechst: blue). The white dotted line represents the edge between the infarct area and the peri-infarct zones, and the white boxes indicate the corresponding area of the enlarged images shown below. (B) Quantification of fluorescence intensity of GFAP and neurocan in panel A. Mean ± SD, n = 3. ^**P < 0.01 vs. sham group; ^#P < 0.05, ^##P < 0.01 vs. I/R group.