TABLE 1.

Significantly altered GO biological process terms.

Description	Measured (n)	Changed (n)	Fold Enrichment	FDR
tRNA processing
GO:0006396 RNA processing	426	106 (Cm = 15, Cn = 91)	1.52	2.4E-02
→ GO:0034660 ncRNA metabolic process	260	88 (Cm = 30, Cn = 58)	2.06	5.2E-06
→ GO:0006399tRNA metabolic process	118	44 (Cm = 22, Cn = 22)	2.27	1.4E-03
→ GO:0009451RNA modification	88	32 (Cm = 9, Cn = 23)	2.21	2.6E-04
→ GO:0034470 ncRNA processing	197	72 (Cm = 14, Cn = 58)	2.22	4.3E-06
→ GO:0008033tRNA processing	73	27 (Cm = 7, Cn = 20)	2.25	3.8E-02
Ribosome biogenesis
GO:0022613 Ribonucleoprotein complex biogenesis	239	69 (Cm = 14, Cn = 55)	1.76	1.0E-02
→ GO:0042254 Ribosome biogenesis	162	60 (Cm = 14, Cn = 46)	2.25	4.3E-05
→ GO:0006364 rRNA processing	105	43 (Cm = 6, Cn = 37)	2.49	2.0E-04
RNA surveillance and catabolism
GO:0071025 RNA surveillance	9	9 (Cm = 0, Cn = 9)	6.09	2.3E-02
→ GO:0071027 Nuclear RNA surveillance	8	8 (Cm = 0, Cn = 8)	6.09	3.4E-02
→ GO:0071028 Nuclear mRNA surveillance	8	8 (Cm = 0, Cn = 8)	6.09	3.6E-02
→ GO:0034475 U4 snRNA 3′-end processing	8	8 (Cm = 0, Cn = 8)	6.09	3.2E-02
→ GO:0016075 rRNA catabolic process	11	9 (Cm = 0, Cn = 9)	4.98	3.6E-02
Drug metabolism
GO:0042737 Drug catabolic process	85	33 (Cm = 2, Cn = 31)	2.36	1.1E-02
Visual perception
GO:0007601 Visual perception	83	31 (Cm = 2, Cn = 29)	2.27	2.3E-02
→ GO:0050953 Sensory perception of light stimulus	88	31 (Cm = 2, Cn = 29)	2.14	3.5E-02

GO terms biological process with FDR < 0.05 were considered to be significantly changed. Cm are changed genes that are linked to mitochondria; Cn are changed genes linked to the nucleus; FDR is false discovery rate.