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. 2020 Jun 12;11:885. doi: 10.3389/fphar.2020.00885

Figure 3.

Figure 3

Administration of PR-957 attenuates Ang II–induced fibrosis and inflammation in mice. (A) Left ventricular sections were stained with Masson’s trichrome to detect fibrosis (left). Scale bar, 50 μm. Quantification of the relative fibrotic area (right, n = 5). (B) Immunohistochemical staining of cardiac macrophages with anti-F4/80 antibody (left). Scale bar, 50 μm. Quantification of the F4/80 positive cells (right, n = 5). (C, D) Quantitative real-time polymerase chain reaction analysis of the mRNA levels of collagen I, collagen III, interleukin (IL)-1β, and IL-6 (n = 5). (D) Data are expressed as mean ± SEM, and n represents the number of animals per group. *P < 0.05, **P < 0.01 vs. saline; #P < 0.05 vs. Ang II ##P < 0.01 vs. Ang II.