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PR-957 inhibits activation of hypertrophic, fibrotic, and inflammatory signaling pathways in mice. (A) Western blot analysis of the protein levels of PTEN, p-AKT, AKT, p-ERK, ERK, TGF-β1, p-p65, p65, p-IkBα, IkBα, and GAPDH in Ang II–infused mice in the presence or absence of PR-957 for 2 weeks. (B) Quantification of each protein band (n = 5). Data are expressed as mean ± SEM, and n represents the number of animals per group. *P < 0.05 vs. saline; #P < 0.05 vs. Ang II.
