TABLE 3.
Top 10 up- and down-regulated genes of Zika-exposed Aedes aegypti relative to uninfected mosquitoes kept at low (20°C), standard (28°C), and high (36°C) temperatures 48 h post-blood-feeding.
| GENES UP-REGULATED |
TEMPERATURE 20°C |
TEMPERATURE 28°C |
TEMPERATURE 36°C |
||||
| Gene ID | Gene Description | Fold Change | q-value | Fold Change | q-value | Fold Change | q-value |
| XP_011493087.1 | Angiotensin-converting enzyme | 14.1809276 | 0.000429978 | ||||
| XP_001652055.1 | Vitellogenic carboxypeptidase-like | 13.75772483 | 0.000429978 | ||||
| XP_001657506.2 | Vitellogenin-A1-like | 11.96534425 | 0.000429978 | ||||
| XP_001657509.1 | Vitellogenin-A1-like | 11.70010847 | 0.000429978 | ||||
| XP_001660818.2 | Vitellogenin-A1 | 10.9320344 | 0.000429978 | ||||
| XP_001652056.2 | Vitellogenic carboxypeptidase | 10.74370729 | 0.000429978 | ||||
| XP_001660472.2 | Alanine aminotransferase 1 | 10.39479931 | 0.000429978 | ||||
| XP_001656695.1 | Argininosuccinate lyase | 10.17572724 | 0.000429978 | ||||
| XP_001648376.1 | Cytochrome P450 4g15 | 10.00001321 | 0.000429978 | ||||
| XP_001659164.1 | Leucine-rich repeat transmembrane neuronal protein 3 | 9.612555348 | 0.000429978 | ||||
| XP_001649098.2 | Probable cytochrome P450 9f2 | 4.118816919 | 0.0027631 | ||||
| XP_001659492.2 | Serine protease SP24D | 3.289321443 | 0.0027631 | ||||
| XP_021698905.1 | Chymotrypsin-2 | 3.165229262 | 0.0027631 | ||||
| XP_001661721.2 | Solute carrier family 45 member 4 | 3.060526797 | 0.0027631 | ||||
| XP_001654886.2 | Zinc carboxypeptidase A 1 | 2.871948741 | 0.0027631 | ||||
| XP_001661388.1 | Chymotrypsin-1 | 2.816727502 | 0.0027631 | ||||
| XP_021698904.1 | Chymotrypsin-2 | 2.669611858 | 0.0027631 | ||||
| XP_021707253.1 | Lipase member H | 2.612389473 | 0.0027631 | ||||
| XP_021697282.1 | Multiple inositol polyphosphate phosphatase 1 | 2.446636883 | 0.0027631 | ||||
| XP_001658491.2 | Trypsin 5G1-like | 2.279646301 | 0.0027631 | ||||
| XP_001652358.2 | Peritrophin-1 | 8.437408782 | 0.00630758 | ||||
| XP_001648381.1 | UNC93-like protein | 7.430915686 | 0.00630758 | ||||
| XP_021710339.1 | Synaptic vesicle glycoprotein 2C | 5.329166839 | 0.00630758 | ||||
| XP_021697715.1 | Peritrophin-1-like | 4.823164447 | 0.00630758 | ||||
| XP_011493129.2 | Flocculation protein FLO11 | 2.282808753 | 0.00630758 | ||||
| XP_021706761.1 | Cysteine sulfinic acid decarboxylase | 2.236697262 | 0.00630758 | ||||
| XP_021707618.1 | Probable chitinase 2 | 2.214805485 | 0.00630758 | ||||
| XP_001658086.2 | Peptidoglycan recognition protein 1 | 2.009494011 | 0.00630758 | ||||
| XP_001649855.2 | Sodium/potassium/calcium exchanger 4 | 1.947834362 | 0.00630758 | ||||
| XP_021709756.1 | ATP-binding cassette sub-family A member 3 isoform X1 | 1.930421649 | 0.00630758 | ||||
| XP_001659797.2 | Beta-1.3-glucan-binding protein | 8.48073909 | 0.000429978 | ||||
| XP_001657206.1 | Cytochrome P450 9e2 | 4.355565374 | 0.000429978 | ||||
| XP_001652358.2 | Peritrophin-1 | 2.847448995 | 0.000429978 | ||||
| XP_021699084.1 | Proton-coupled amino acid transporter 1-like | 2.551861447 | 0.000429978 | ||||
| XP_001659796.1 | Beta-1.3-glucan-binding protein | 2.517270058 | 0.000429978 | ||||
| XP_001649098.2 | Probable cytochrome P450 9f2 | 2.415932254 | 0.000429978 | ||||
| XP_001649745.1 | Very long-chain specific acyl-CoA dehydrogenase mitochondrial | 2.281021429 | 0.000429978 | ||||
| XP_001654398.2 | rRNA 2’-O-methyltransferase fibrillarin | 2.204742243 | 0.000429978 | ||||
| XP_001661250.1 | Peroxiredoxin-6 | 1.971170346 | 0.000429978 | ||||
| XP_001649797.1 | Peptide methionine sulfoxide reductase | 1.965683434 | 0.000429978 | ||||
| XP_001652056.2 | Vitellogenic carboxypeptidase | 6.420385839 | 0.0027631 | ||||
| XP_001655729.2 | Tryptase | 5.300762859 | 0.0027631 | ||||
| XP_001647719.2 | Transferrin | 4.298907297 | 0.0027631 | ||||
| XP_001655031.2 | Carbonic anhydrase 2 | 3.707662693 | 0.0027631 | ||||
| XP_011493147.1 | Glycine-rich protein 5 | 3.626857343 | 0.0027631 | ||||
| XP_001651077.2 | Synaptic vesicle glycoprotein 2B | 3.02148965 | 0.0027631 | ||||
| XP_001659383.2 | Angiopoietin-related protein 1 | 2.46044625 | 0.0027631 | ||||
| XP_001651411.2 | Lysosomal alpha-mannosidase | 2.427598779 | 0.0027631 | ||||
| XP_001656519.2 | Solute carrier family 22 member 21 isoform X2 | 2.425681278 | 0.0027631 | ||||
| XP_011493149.1 | Hyphally-regulated protein | 2.384835903 | 0.0049383 | ||||
| XP_021696806.1 | Pupal cuticle protein Edg-78E | 18.1975207 | 0.00630758 | ||||
| XP_011493274.2 | Extensin | 3.699473591 | 0.00630758 | ||||
| XP_001661011.1 | Protein lethal(2)essential for life | 3.215359388 | 0.00630758 | ||||
| XP_001658359.2 | Brachyurin | 2.357013464 | 0.00630758 | ||||
| XP_001649783.1 | Maltase 1 | 1.680632876 | 0.0148679 | ||||
| XP_001647586.2 | Asparagine synthetase [glutamine-hydrolyzing] 1 | 1.637484216 | 0.00630758 | ||||
| XP_021694990.1 | Myrosinase 1-like | 1.626761779 | 0.00630758 | ||||
| XP_021693649.1 | Heat shock protein 70 A1 | 1.55902061 | 0.02715 | ||||
| XP_001651895.1 | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 | 1.523434001 | 0.00630758 | ||||
| XP_001649752.1 | Heat shock protein 83 | 1.48484568 | 0.00630758 | ||||