Table.
Clinicopathologic Characteristics of the Seven NEC and MANEC Cases, with Detailed Descriptions, in the Literature.
| No | Year | Reference | Age | Sex | Location | Size (mm) |
Type | Histopathological diagnosis at biopsy |
First treatment | Final histopathological diagnosis |
Depth | Additional treatment |
Turning point |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 1998 | (12) | 60 | F | Body | 20×15 | Not stated | Adenocarcinoma | Gastrectomy | Adeno. NEC | SM | None | 36 mo. survival |
| 2 | 2013 | (13) | 67 | M | Antrum | 35×35 | Not stated | Not stated | Gastrectomy | Pure NEC | SM2 | None | 8 mo. survival |
| 3 | 2014 | (14) | 80 | M | Body | 10×9 | 0-IIc | Adenocarcinoma (moderate) | ESD | MiNEN | SM2 | Gastrectomy | 36 mo. survival |
| 4 | 2015 | (15) | 77 | M | Antrum | 10×6 | 0-IIc | Adenocarcinoma (moderate) | ESD | MiNEN | M | None | 7 mo. survival |
| 5 | 2016 | (16) | 63 | M | Angle | 23×20 | 0-IIc | Adenocarcinoma (moderate) | Gastrectomy | MiNEN | SM2 | Chemotherapy | 16 mo. survival |
| 6 | 2018 | (17) | 70 | M | Antrum | 17×9 | 0-IIc | Adenocarcinoma (well) | ESD | MiNEN | SM1 | Gastrectomy and chemotherapy |
50 mo. survival |
| 7 | 2019 | Our case | 74 | F | Antrum | 11×10 | 0-IIa+IIc | Pure NEC | Gastrectomy | Pure NEC | SM2 | None | 18 mo. survival |
Results were obtained with a PubMed search (cases between 1998–2018).
SM: submucosa, Adenocarcinoma (moderately): moderately differentiated tubular adenocarcinoma, Adenocarcinoma (well): well-differentiated tubular adenocarcinoma, Adeno.: adenocarcinoma, Pure NEC: NEC without an adenocarcinomatous component, MiNEN: mixed neuroendocrine-non-neuroendocrine neoplasm