TABLE 1.
Patient characteristics by outcome.
| All patients N = 25,497 | Incident chronic kidney condition n = 570 | Incident acute kidney condition n = 190 | Death without kidney disease n = 3,199 | No event (censor) n = 21,538 | |
| Demographics | |||||
| Age in years, median (IQR) | 58.1 (40.3–73.7) | 72.5 (58.2–81.8) | 68.5 (56.3–77.0) | 79.4 (69.2–87.2) | 54.0 (37.4–69.6) |
| Female, n (%) | 13,373 (52.5%) | 265 (46.5%) | 73 (38.4%) | 1,697 (53.0%) | 11,338 (52.6%) |
| Chronic disease status | |||||
| Hypertension, n (%) | 2,745 (10.8%) | 131 (23.0%) | 38 (20.0%) | 624 (19.5%) | 1,952 (9.1%) |
| Cardiovascular disease, n (%) | 2,534 (9.9%) | 123 (21.6%) | 35 (18.4%) | 745 (23.3%) | 1,631 (7.6%) |
| Chronic pulmonary disease, n (%) | 2,160 (8.5%) | 67 (11.8%) | 36 (18.9%) | 595 (18.6%) | 1,462 (6.8%) |
| Diabetes, n (%) | 1,601 (6.3%) | 108 (18.9%) | 44 (23.2%) | 362 (11.3%) | 1,087 (5.0%) |
| Cancer, n (%) | 1,291 (5.1%) | 42 (7.4%) | 11 (5.8%) | 653 (20.4%) | 585 (2.7%) |
| Dementia, n (%) | 505 (2.0%) | 13 (2.3%) | 3 (1.6%) | 264 (8.3%) | 225 (1.0%) |
| Liver disease, n (%) | 362 (1.4%) | 11 (1.9%) | 11 (5.8%) | 76 (2.4%) | 264 (1.2%) |
| Peptic ulcer disease, n (%) | 226 (0.9%) | 11 (1.9%) | 5 (2.6%) | 54 (1.7%) | 156 (0.7%) |
| Othera, n (%) | 465 (1.8%) | 19 (3.3%) | 8 (4.2%) | 100 (3.1%) | 338 (1.6%) |
| Hospital admission | |||||
| Received surgery during hospitalization, n (%) | 230 (0.9%) | 3 (0.5%) | 2 (1.1%) | 24 (0.8%) | 201 (0.9%) |
| Length of stay in days, median (IQR) | 1 (0–3) | 2 (1–6) | 2 (1–7) | 3 (1–8) | 1 (0–2) |
| Acute readmission during follow-up: | |||||
| Within 30 days, n (%) | 3,911 (15.3%) | 154 (27.0%) | 64 (33.7%) | 1,119 (35.0%) | 2,574 (12.0%) |
| Within 90 days, n (%) | 6,058 (23.8%) | 251 (44.0%) | 101 (53.2%) | 1,596 (49.9%) | 4,110 (19.1%) |
| Biomarkers | |||||
| eGFR in mL/min/1.73 m2, median (IQR)b | 88.7 (69.8–104.7) | 54.0 (36.3–84.6) | 72.6 (49.7–93.2) | 69.8 (50.0–87.7) | 91.5 (74.7–106.7) |
| <60 mL/min/1.73 m2, n (%) | 3,987 (16.4%) | 311 (57.2%) | 68 (37.0%) | 1,180 (38.2%) | 2,428 (11.8%) |
| ≥60 mL/min/1.73 m2, n (%) | 20,323 (83.6%) | 233 (42.8%) | 116 (63.0%) | 1,908 (61.8%) | 18,066 (88.2%) |
| CRP in mg/L, median (IQR)b | 4 (1–22) | 10 (3–50) | 9 (3–55) | 19 (5–70) | 4 (1–15) |
| suPAR in ng/mL, median (IQR)b | 2.7 (2.0–3.9) | 4.2 (2.9–5.8) | 4.6 (3.1–6.3) | 4.5 (3.3–6.2) | 2.5 (1.9–3.5) |
aIncludes connective tissue disease, paraplegia/hemiplegia, and HIV/AIDS. bMeasured at index admission; 1,187 patients (4.7%) missing value for eGFR and C-reactive protein. CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; IQR, interquartile range; suPAR, soluble urokinase plasminogen activator receptor.