TABLE 2.
Association of log2(suPAR) with development of incident chronic and acute kidney conditions.
| Endpoint | No. patients | Median (IQR) eGFRa (mL/min/1.73 m2) | Median (IQR)a suPAR (ng/mL) | Hazard Ratio (95% CI)b | |
| Univariate | Multivariatec | ||||
| Chronic kidney condition | 570 | 54.0 (36.3–84.6) | 4.2 (2.9–5.8) | 2.52 (2.31–2.75) | 1.57 (1.38–1.78) |
| Chronic kidney disease | 263 | 41.2 (30.6–58.4) | 4.8 (3.6–6.3) | 3.20 (2.84–3.60) | 1.77 (1.47–2.13) |
| Glomerular disease | 23 | 73.1 (52.8–98.0) | 3.2 (2.0–5.8) | 1.64 (1.00–2.67) | 1.13 (0.60–2.14) |
| Tubulointerstitial disease | 185 | 82.7 (56.8–107.0) | 3.2 (2.2–4.6) | 1.56 (1.31–1.86) | 1.26 (1.00–1.59) |
| Other renal disorder | 99 | 47.0 (33.6–71.5) | 4.6 (3.5–6.3) | 2.99 (2.46–3.65) | 2.07 (1.56–2.76) |
| Acute kidney condition | 190 | 72.6 (49.7–93.2) | 4.6 (3.1–6.3) | 2.96 (2.57–3.42) | 2.51 (2.09–3.01) |
| <30 days from index | 24 | 75.1 (59.3–93.5) | 4.7 (3.9–6.3) | 2.99 (2.01–4.44) | 2.43 (1.45–4.06) |
| 30–90 days from index | 29 | 74.6 (54.0–93.6) | 5.0 (3.1–7.4) | 2.96 (2.06–4.26) | 2.67 (1.70–4.20) |
| >90 days from index | 137 | 69.9 (47.2–92.9) | 4.6 (2.9–6.2) | 2.96 (2.50–3.51) | 2.49 (2.01–3.09) |
aMeasured at index admission; 1,187 patients (4.7%) missing value for eGFR. bHazard ratios represent the proportional risk of developing the given kidney condition for each doubling in suPAR and is evaluated for the entire duration of follow-up unless otherwise specified. cAdjusted for age, sex, log2(eGFR), log10(CRP), cardiovascular disease, hypertension, and diabetes. CI, confidence interval; eGFR, estimated glomerular filtration rate; IQR, interquartile range; suPAR, soluble urokinase plasminogen activator receptor.