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. 2020 Jun 19;5:100. doi: 10.1038/s41392-020-0211-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Levels of CCGFs increased in COVID-19 patients. a Levels of CCGFs that were increased in COVID-19 patients but not correlated to disease severity. b Levels of CCGFs that were increased in COVID-19 patients and positively correlated to COVID-19 disease severity. c Levels of CCGFs that were increased in COVID-19 patients and negatively correlated to COVID-19 disease severity. Dynamic levels of the indicated CCGFs in plasma samples of mild (n = 10), severe (n = 7), and fatal (n = 6) COVID-19 patients at the indicated days after diagnosis as well as healthy individuals (n = 4) were measured by Bio-plex. Data shown are averages plus SD of the CCGF levels in mild, severe, and fatal COVID-19 patients, and averages of the CCGF levels in healthy individuals (dotted line). *p < 0.05; **p < 0.01 (Turkey’s test as described in Supplementary Information)