Table 2.
Cox proportional hazards analysis of the effect of age, sex, and treatment on NMSCs and NHL risk in IBD patients [MDV database].
| Malignancy and risk factor | Parameter estimate | SEM | p-value | HR |
|---|---|---|---|---|
| NMSCs | ||||
| Sex | 0.24 | 0.31 | 0.434 | 1.28 |
| Age | 0.09 | 0.01 | <0.0001 | 1.09 |
| Thiopurine only | 1.59 | 0.37 | <0.0001 | 4.92 |
| Anti-TNFα only | –13.19 | 724.68 | 0.986 | 0.00 |
| Thiopurine and anti-TNFα | 1.63 | 0.48 | 0.001 | 5.08 |
| NHL | ||||
| Sex | 0.15 | 0.20 | 0.457 | 1.16 |
| Age | 0.04 | 0.01 | <0.0001 | 1.04 |
| Thiopurine only | 0.21 | 0.32 | 0.518 | 1.23 |
| Anti-TNFα only | 0.28 | 0.38 | 0.455 | 1.33 |
| Thiopurine and anti-TNFα | 0.54 | 0.32 | 0.094 | 1.71 |
HR, hazard ratio; IBD, inflammatory bowel disease [ulcerative colitis/Crohn’s disease]; MDV, Medical Data Vision; NHL, non-Hodgkin lymphoma; NMSC, non-melanoma skin cancer; SEM, standard error of the mean; TNFα, tumor necrosis factor-alpha.