Table II.
Summary of large case series and registry data of autoimmune disease patients infected or exposed to SARS-CoV-2
| Characteristics∗ | Studies |
||
|---|---|---|---|
| Haberman et al71 | Gianfrancesco et al72 | Brenner et al73 | |
| Total number of patients† | 86 | 110 | 525 |
| Confirmed cases of COVID-19 | 59 (69) | 110 (100) | 525 (100) |
| Age, mean y | 46 | N/A‡ | 43 |
| Female sex | 49 (57) | 79 (72) | 243 (46.3) |
| Most common diagnosis | PsA: 21 (24) | RA: 40 (36) | CD: 312 (59.4) |
| Other diagnoses | RA: 20 (23) | PsA: 19 (17) | UC: 203 (38.7) |
| CD: 20 (23) | SLE: 19 (17) | IBD unspecified: 7 (1.3) | |
| UC: 17 (20) | Other: 17 (15)§ | ||
| Psoriasis: 14 (16) | AS: 7 (6) | ||
| AS: 9 (10) | Vasculitis: 7 (6) | ||
| SjS: 5 (5) | |||
| Medications | |||
| Biologic drugs | TNFi: 38 (44) | Unspecified: 49 (45) | TNFi alone: 176 (33.5) |
| IL-17i: 6 (7) | IL-12/23i: 55 (10.5) | ||
| IL-12/23i: 6 (7) | TNFi + DMARD: 52 (9.9) | ||
| IL-23i: 3 (3) | α-Integrin: 50 (9.5) | ||
| JAKi | 6 (7) | 5 (5) | 8 (1.5) |
| csDMARD | MTX: 17 (20) | 69 (63) | 110 (21) |
| Hydroxychloroquine | 8 (9) | N/A | 0 |
| Hospitalization | 14 (16) | 39 (35) | 161 (31) |
| Deaths | 1 (1) | 6 (5) | 16 (3) |
AS, Ankylosing spondylitis; CD, Crohn's disease; COVID-19, coronavirus disease 2019; csDMARD, conventional synthetic disease-modifying antirheumatic drug; IBD, inflammatory bowel disease; IL, interleukin; JAK, Janus kinase inhibitor; MTX, methotrexate; N/A, not available; PsA, psoriatic arthritis; RA, rheumatoid arthritis; SARS-Cov-2, severe acute respiratory syndrome coronavirus 2; SjS, Sjögren syndrome; SLE, systemic lupus erythematosus; TNFi, tumor necrosis factor-α inhibitor; UC, ulcerative colitis.
Data are shown as number (%) or as indicated otherwise.
Includes both confirmed and highly suspected cases of COVID-19.
20% of patients were aged >65 years.
Other included (all with n < 5): inflammatory myopathy, ocular inflammation, other inflammatory arthritis, polymyalgia rheumatica, sarcoidosis, systemic sclerosis, osteoporosis, psoriasis, isolated pulmonary capillaritis, gout, and autoinflammatory disease.