Figure 6.
Local Sensitivity Analyses (LSA) and Global Sensitivity Analyses (GSA) Integrate Th1-Related Phenotypes to Simulate Antitumor Effect of PD-1 Blockade
(A) Relative sensitivities determined by LSA for the top 15 kinetic parameters (indicated by parameter number).
(B) Relative sensitivities determined by LSA for initial cytokine levels and initial T cell populations. For (A) and (B), the Log10 of the absolute value of the relative sensitivities are presented for visual clarity.
(C) Decrease in cancer cell population at t = 72 h with PD-1 blockade as a function of Th1 induction, obtained by changing only the initial cancer cell population. Initial cancer cell population comprises less than 75% of the tumor for points to the left of the dashed vertical line.
(D) MPSA sensitivities determined by GSA for the initial protein levels and initial relative T cell populations.
(E) MPSA sensitivities determined by GSA for the top 20 kinetic parameters (indicated by parameter number).
(F) MPSA sensitivities determined by GSA for the initial cytokine levels and T cell populations. In (E) and (F), all protein levels, initial T cell populations, initial cancer cell population, and kinetic parameters were varied.