The volumetric profile of thalamic nuclei in healthy controls (HC), primary lateral sclerosis (PLS), C9orf72 positive ALS patients (ALS-C9+), and C9orf72 negative ALS patients (ALS-C9-) based on estimated marginal means adjusted for age, gender, total intracranial volumes (TIV) and education. Error bars represent 95% confidence intervals. Inter-group differences corrected for multiple comparisons are highlighted with asterisks * p < 0.05 ** p < 0.01.