Table 2.
Subcortical grey matter volumes (mm3) in healthy controls (HC), C9orf72 positive ALS patients (ALS-C9 + ), C9orf72 negative ALS patients (ALS-C9-) and PLS patients (PLS). Estimated marginal means and standard error are adjusted for age, gender, education and total intracranial volume (TIV). Significant intergroup differences at p < 0.05 after FDR-correction for multiple comparisons are flagged in bold print.
| Nuclei | Study group | EMM | Standard error | C9+ ALS vs HC | C9- ALS vs HC | PLS vs HC | C9+ vs C9- | C9+ ALS vs PLS | C9- ALS vs PLS |
|---|---|---|---|---|---|---|---|---|---|
| Anteroventral | HC | 120.348 | 1.606 | 0.072 | 0.011 | 0.308 | 0.502 | 0.330 | 0.498 |
| ALS-C9+ | 108.247 | 4.985 | |||||||
| ALS-C9- | 112.701 | 1.843 | |||||||
| PLS | 115.716 | 3.004 | |||||||
| Lateral geniculate | HC | 166.002 | 1.903 | 0.227 | 0.378 | <0.001 | 0.483 | 0.486 | 0.014 |
| ALS-C9+ | 156.178 | 5.908 | |||||||
| ALS-C9- | 162.525 | 2.184 | |||||||
| PLS | 149.874 | 3.560 | |||||||
| Medial geniculate | HC | 109.069 | 1.289 | 0.085 | 0.038 | 0.483 | 0.483 | 0.300 | 0.498 |
| ALS-C9+ | 99.915 | 4.000 | |||||||
| ALS-C9- | 104.013 | 1.479 | |||||||
| PLS | 106.428 | 2.411 | |||||||
| Pulvinar-limitans | HC | 1511.829 | 12.094 | 0.963 | 0.680 | 0.011 | 0.879 | 0.178 | 0.035 |
| ALS-C9+ | 1510.012 | 37.536 | |||||||
| ALS-C9- | 1502.542 | 13.880 | |||||||
| PLS | 1432.716 | 22.622 | |||||||
| Laterodorsal | HC | 23.301 | .692 | 0.212 | 0.072 | 0.300 | 0.666 | 0.072 | 0.017 |
| ALS-C9+ | 19.607 | 2.148 | |||||||
| ALS-C9- | 20.893 | .794 | |||||||
| PLS | 25.344 | 1.295 | |||||||
| Lateroposterior | HC | 112.576 | 1.480 | 0.142 | 0.037 | 0.680 | 0.605 | 0.289 | 0.308 |
| ALS-C9+ | 103.304 | 4.594 | |||||||
| ALS-C9- | 106.652 | 1.699 | |||||||
| PLS | 110.981 | 2.769 | |||||||
| Mediodorsal-paratenial-reuniens | HC | 952.485 | 8.870 | <0.001 | <0.001 | <0.001 | 0.085 | 0.483 | 0.207 |
| ALS-C9+ | 831.611 | 27.532 | |||||||
| ALS-C9- | 895.909 | 10.180 | |||||||
| PLS | 863.272 | 16.593 | |||||||
| Motor Hub | HC | 1823.542 | 15.441 | 0.161 | 0.007 | 0.014 | 0.826 | 0.950 | 0.670 |
| ALS-C9+ | 1730.548 | 47.926 | |||||||
| ALS-C9- | 1744.318 | 17.721 | |||||||
| PLS | 1726.039 | 28.884 | |||||||
| Sensory Hub | HC | 870.109 | 8.949 | 0.498 | <0.001 | <0.001 | 0.483 | 0.165 | 0.227 |
| ALS-C9+ | 844.262 | 27.777 | |||||||
| ALS-C9- | 816.158 | 10.271 | |||||||
| PLS | 785.381 | 16.740 | |||||||
| Intralaminar | HC | 407.634 | 3.941 | 0.609 | 0.007 | 0.017 | 0.484 | 0.407 | 0.699 |
| ALS-C9+ | 399.285 | 12.231 | |||||||
| ALS-C9- | 387.102 | 4.523 | |||||||
| PLS | 383.145 | 7.371 | |||||||
| Whole thalamus | HC | 6096.895 | 43.005 | 0.098 | <0.001 | <0.001 | 0.774 | 0.605 | 0.212 |
| ALS-C9+ | 5802.968 | 133.480 | |||||||
| ALS-C9- | 5852.813 | 49.356 | |||||||
| PLS | 5698.896 | 80.445 |