Figure 3.

GPLs’ fatty acid compositions in OSCC (blue) and healthy (orange) tissue. (A) Composition of fatty acid species within the GPLs. In the graph, fatty acids have been shown separated by 1) those with <2 double bonds and ≥2 double bonds, 2) the number of double bonds, 3) chain length and number of double bonds, and 4) chain length. The area of each circle is proportional to the abundance of each fatty acid moiety in pmol/mg tissue. Only lipids that are significant after using the Benjamini-Hochberg multiple testing correction are shown with an asterisk (*). (B) Structures of the different GPLs. Additionally, the compositions of the phosphatidylcholine ether and phosphatidylethanolamine ether were included (structures not shown). R1 and R2: variable fatty acid chains. (C) An overview of the Kennedy pathway.