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. 2020 Jun 2;23(6):101226. doi: 10.1016/j.isci.2020.101226

Figure 2.

Figure 2

MSPs Protect against DSS Colitis in Germ-Free Mice

(A) Extracellular fecal purine metabolite analyses of GF-CNTL and GF mice colonized with E. coli K12 (GF-K12).

(B) Weight curves of GF-CNTL and GF-K12 mice subjected to DSS colitis (GF-CNTL/K12-DSS; n = 5).

(C) Survival curves of GF-CNTL-DSS and GF-K12-DSS mice subjected to DSS colitis.

(D) Colon tissue adenylate metabolite analyses of GF-CNTL, GF-K12, and GF-K12-DSS mice.

(E) Total purine metabolite levels from GF-CNTL, GF-K12, and GF-K12-DSS extracts. Total purine is the sum of adenylate metabolites presented.

(F) Colon tissue phosphocreatine analyses of GF-CNTL, GF-K12, and GF-K12-DSS mice.

(G) Graphical summary of MSP salvage for ATP genesis. Data are represented as mean ± SEM (n = 5). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001; Hpx, hypoxanthine; Xan, xanthine, Ino, inosine; AMP, adenosine monophosphate; ADP, adenosine diphosphate; ATP, adenosine triphosphate; PCr, phosphocreatine; Cr, creatine.