Table 5.
Effect of dietary RAPA and CQ on intestinal morphology following exposure to DON.
| Parameters | CON | DON | RAPA+DON | CQ+DON | SEM | P value |
|---|---|---|---|---|---|---|
| Jejunum | ||||||
| Villus height (μm) | 352.63a | 323.54b | 259.51c | 341.10a | 19.93 | <0.01 |
| Crypt depth (μm) | 86.70b | 97.31a | 78.21c | 90.20b | 3.46 | <0.01 |
| Villus height: crypt | 4.07a | 3.33c | 3.32c | 3.79b | 0.09 | <0.01 |
| Wall thickness (μm) | 159.24bc | 182.40a | 150.12c | 166.48b | 4.72 | <0.01 |
| Goblet cell number | 8.50 | 9.17 | 8.17 | 7.67 | 0.14 | 0.32 |
| Lymphocyte number | 31.50a | 30.00a | 27.83b | 30.67a | 0.10 | <0.01 |
| Ileum | ||||||
| Villus height (μm) | 325.30a | 267.71c | 223.00d | 297.78b | 20.14 | <0.01 |
| Crypt depth (μm) | 89.19a | 88.27a | 77.80b | 87.54a | 2.81 | <0.01 |
| Villus height: crypt | 3.65a | 3.16b | 2.87c | 3.42a | 0.14 | <0.01 |
| Wall thickness (μm) | 160.20a | 168.36a | 94.80 b | 159.06a | 17.59 | <0.01 |
| Goblet cell number | 10.17 | 9.33 | 10.67 | 11.67 | 0.29 | 0.29 |
| Lymphocyte number | 31.50 | 29.67 | 30.50 | 29.33 | 0.10 | 0.25 |
CON: saline solution; DON: deoxynivalenol diet and saline solution; RAPA+DON: rapamycin and deoxynivalenol diet; CQ+DON: chloroquine and deoxynivalenol diet. a,b,cValues within a row with different superscripts differ significantly (P < 0.05). If “ab” is in the marked place the measurement is neither significant compared to “a” or “b”, the same of other.