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Hyperoxia causes lung injury in HO-1 KO and wild-type mice. Adult (7-12 wks) wild-type and HO-1 KO mice were continuously exposed to >95% O2 for 72 h. (a) Right lung/body weight ratios were calculated. Data (mean ± SD, n = 7 − 8) were analyzed by two-way ANOVA followed by Tukey's post hoc analysis (∗p = 0.0007 vs wild-type/room air; #p = 0.0003 vs HO-1 KO/room air). An independent effect of hyperoxia was detected (p < 0.0001). (b–e) Representative H&E stained sections.
