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Schematic representation of the main lines of evidence for increased metabolic efficiency, consequent to reduced energy expenditure, in ob/ob mice. (a) Milk intake in suckling ob/ob and +/? mice; (b) pair-feeding studies in which ob/ob mice were fed the ad libitum intake of lean siblings; (c) metabolic rate ‘per animal’ at temperatures below thermoneutrality. Mouse images are courtesy of Servier Medical Art (https://smart.servier.com).
