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a) Chemical structures of the rHyP series. b) Normalized absorbance and c) PA spectra of rHyP-1 and red-rHyP-1 in CHCl3. d) PA images of rHyP-1 solutions treated with RLMs in normoxic and hypoxic conditions. e) Ratiometric PA signal in 2 mm slices of a PA reconstruction of a 4T1 tumor following administration of rHyP-1. f) Ratiometric PA fold turn-on of rHyP-1 in tumor-bearing and control flanks. g) Representative PA 3D reconstruction of a 4T1 tumor following administration of rHyP-1.
