Figure 1.

Dextran sulfate sodium (DSS)-induced pathological changes in MK2^lyz2−WT and MK2^lyz2−KO mice. Male and female mice (7–10 weeks) were used in the experiments. (A) The body weight changes of MK2^lyz2−WT and MK2^lyz2−KO mice receiving 3.5% DSS or water control for up to 7 days. (B) Macroscopic examination of colon lengths of MK2^lyz2−WT and MK2^lyz2−KO mice after 7 days' treatment of 3.5% DSS or water control. (C) Statistical analysis of colon lengths. (D) Representative images of H&E-stained colon sections from control and DSS-treated mice. Scale bars: 200 μm (upper), 40 μm (lower). (E) Statistical analysis of histological scores. (F) The protein levels of interleukin (IL)-6 in colon tissues detected by ELISA. (G) The protein levels of tumor necrosis factor (TNF)-α in colon tissues detected by ELISA. (H) Myeloperoxidase (MPO) activity in the colon tissues. The results were shown as means ± SEM. *P < 0.05; **P < 0.01 based on six mice in each group.