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. 2020 Jun 19;35(3):701–711. doi: 10.1038/s41375-020-0892-z

Fig. 6. Tranylcypromine plasma concentrations, intracellular concentrations and H3K4-dimethylation of selected study patients.

Fig. 6

a TCP plasma concentrations of indicated study patients at screening and during treatment course. All patients reached the maximum TCP dose of 60 mg/day by day 7. b Intracellular TCP concentrations of indicated study patients at screening and during treatment course. c H3K4me1, H3K4me2, totalH3, LSD1 and Actin protein expression of indicated study patients at screening and during treatment course. H3K4me1/totalH3 and H3K4me2/totalH3 ratios were calculated using ImageJ. Ratios at screening are depicted as a reference value of “1”. Ratios obtained at additional treatment time points are set in proportion accordingly.