Figure 2.

Network of eligible comparisons

(A) Efficacy. (B) Acceptability. The width of the lines is proportional to the number of trials comparing every pair of treatments, and the size of each node is proportional to the number of randomly assigned participants. AMI=Amitriptyline. BT=Behavioural therapy. CBT=cognitive-behavioural therapy. CIT=citalopram. CLO=clomipramine. DYN=psychodynamic therapy. DES=desipramine. DEV=desvenlafaxine. DUL=duloxetine. ESC=escitalopram. FT=family therapy. FLU=fluoxetine. IPT=interpersonal therapy. IMP=imipramine. MIR=mirtazapine. NEF=nefazodone. NOR=nortriptyline. PST=problem-solving therapy. PAR=paroxetine. Pill PBO=pill placebo. Psy PBO=psychological placebo. SUP=supportive therapy. SER=sertraline. TAU=treatment as usual. VEN=venlafaxine. VIL=vilazodone. WL=waiting list.