Figure 8.

Expression of the Progenitor Cell Transcription Factors and Basal Cell Markers in Adult Human LGs

(A–F) Similar to mouse LGs (Makarenkova et al., 2000), PAX6 (A) is expressed in the distal epithelial structures, whereas KRT5 (B) and KRT14 (C) are expressed in ductal epithelial derivates. SOX9 (D and E) is found in the nuclei of LG epithelium, whereas SOX10 (F) is restricted to the nuclei of acinar cells.

(G) THBS1 is expressed in MECs (MECs, white arrows) and ducts (ducts, red arrows).

(H) Negative control: section was treated with nonspecific IgG. Human LGs from three female donors (ages at the time of death were 62, 84, and 90 years) were obtained from Advanced Tissue Services (Phoenix, AZ, USA).

See also Figure S8.