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. 2020 Jun 17;6(6):e04162. doi: 10.1016/j.heliyon.2020.e04162

Figure 3.

Figure 3

Anti-psoriatic effect of Pep3D assayed in psoriasis murine models. (a) The Pep3D assayed at 2 and 20 ng in the murine psoriasis models induced with IMQ or TPA in the back of the animals. An irrelevant peptide (PepIrre) and betamethasone (bMT) were used as controls. The dotted lines in color correspond to: area of the skin treated with the inductor of psoriasis (purple line), treated with Pep3D or PepIrre (red line), and not-treated skin (green line). The anti-psoriatic effect of Pep3D was also assayed in the ear of mice induced with IMQ (b) and TPA (d) (3 mice per group of treatment). Histochemistry analysis of the ears treated with Pep3D in IMQ model (c) and TPA model (e). Epidermis area is delimited with black dotted lines. The anti-inflammatory βMT, and acetone as solvent of TPA, were used as controls.