Table 1.
Clinical characteristics of the study population
| IL10RA | CD | HC | P value1 | |
| Number of samples | 17 | 17 | 26 | |
| Demographics | ||||
| Age (mean ± SD, yr) | 1.00 ± 0.68 | 8.92 ± 4.80 | 1.61 ± 1.71 | < 0.001 |
| Sex (M/F) | 10/7 | 11/6 | 17/9 | 0.724 |
| Weight and BMI | ||||
| Weight (mean ± SD, kg) | 7.31 ± 2.58 | 27.18 ± 13.04 | NA | < 0.001 |
| BMI (mean ± SD) | 14.53 ± 2.20 | 15.25 ± 2.44 | NA | 0.6175 |
| Disease activity | ||||
| CRP (mean ± SD, mg/L) | 40.65 ± 28.13 | 34.06 ± 31.92 | NA | 0.4486 |
| wPCDAI (mean ± SD) | 52.21 ± 17.65 | 40.88 ± 20.02 | NA | 0.1253 |
| SES-CD (mean ± SD) | 20.56 ± 7.56 | 12.94 ± 8.60 | NA | 0.0158 |
| MINI index (mean ± SD) | 19.88 ± 4.96 | 16.47 ± 2.92 | NA | 0.0027 |
| Disease duration and anemia | ||||
| Disease duration (mean ± SD, mo) | 9.93 ± 7.75 | 7.10 ± 9.30 | NA | 0.0706 |
| Disease location | ||||
| Ileum only (%) | 0 (0) | 3 (18) | NA | < 0.001 |
| Colon only (%) | 17 (100) | 3 (18) | NA | |
| Both (%) | 0 (0) | 11 (64) | NA | |
| Disease behaviour | ||||
| Montreal classification B1 (%) | 11 (65) | 15 (88) | NA | 0.106 |
| Montreal classification B2 (%) | 5 (29) | 2 (12) | NA | 0.203 |
| Montreal classification B3 (%) | 4 (24) | 0 (0) | NA | 0.033 |
| Montreal classification P (%) | 16 (94) | 4 (24) | NA | < 0.001 |
| Serology | ||||
| IL6 (mean ± SD, pg/mL) | 122.47 ± 152.22 | 37.50 ± 25.08 | NA | 0.0211 |
| Birth and breast feeding | ||||
| Cesarian section (%) | 11 (65) | 8 (47) | NA | 0.300 |
| Breast feeding (%) | 14 (82) | 13 (76) | NA | 0.671 |
| IBD medication | ||||
| Mesalazine (%) | 11 (65) | 11 (65) | NA | 1.000 |
| Steroids (%) | 1 (6) | 2 (12) | NA | 0.542 |
| Thalidomide (%) | 4 (24) | 0 (0) | NA | 0.014 |
| Other medication | ||||
| Antibiotics (%) | 13 (76) | 13 (76) | NA | 1.000 |
| Proton pump inhibitors (%) | 1 (6) | 9 (53) | NA | 0.001 |
| Marzulene-S (%) | 1 (6) | 1 (6) | NA | 1.000 |
| Self-reported diets | ||||
| Amino acid formula (%) | 2 (12) | 0 (0) | NA | 0.089 |
| Extensive hydrolyzed formula (%) | 3 (18) | 1 (6) | NA | 0.277 |
| Other diet (%) | 12 (71) | 10 (59) | NA | 0.473 |
1
P value for the comparison between IL10RA group and CD group. IL10RA: IL10RA group; CD: Crohn's disease group; HC: Healthy control group; NA: Not applicable; BMI: Body mass index; CRP: C-reactive protein; wPCDAI: Weighted pediatric Crohn's disease activity index; SES-CD: Simple endoscopic score for Crohn's disease; MINI: Mucosal-inflammation non-invasive; IL6: Interleukin 6.